|(1S,4aS,7aS)-甲基 7-(羟甲基)-1-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃- 2-基)氧基)-1,4a,5,7a-四氢环戊烷并[c]吡喃-4-羧酸酯|CsnPharm

CAS No.: 24512-63-8

京尼平甙 Catalog No. CSN17229

Synonyms: 栀子苷

Geniposide, a natural product isolated and purified from the fruit of Gardenia jasminoides Ellis., can induce increased activity of phase II detoxifying enzymes, inhibit tumor promotion, and induce apoptosis in rat C6 glioma cells. Geniposide can also be transformed to blue pigments by a simple modification, may be used as a value-added food colorant, and shows a greater protective effect on the granule cell layer than on the pyramidal cell layer including CA 1 and CA 3.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Geniposide (GEN), a kind of iridoid glycoside extracted from Gardenia jasminoides fruit, has many biological effects, such as resistance to cell damage and anti-neurodegenerative disorder. GEN has protective effect on lipid accumulation via enhancing the ability of antioxidative stress and anti-inflammation which were mostly depend on up-regulating the protein expression of Nrf2/HO-1 (nuclear factor erythroid-2-related factor 2/haeme oxygenase) and AMPK (adenosine 5'-monophosphate-activated protein kinase) signalling pathways, thereby suppressed the phosphorylation of mTORC (mechanistic target of rapamycin complex) and its related protein^[3]. Moreover, geniposide (10, 20 and 40 mg/kg) could significantly ameliorate acute kidney injury in CLP (cecal ligation and puncture)-induced septic mice and LPS-stimulated HK-2 cells by activating PPARγ^[4]. Geniposide was able to increase autophagy and inhibit apoptosis by regulating the function of mTOR in treating Alzheimer's disease. Geniposide has also been shown to act as a glucagon-like peptide-1 receptor (GLP-1R) agonist to reduce amyloid plaques and inhibit oxidative stress to alleviate memory impairment as well as synaptic loss^[5]. Geniposide could inhibit the progression of and stabilize atherosclerotic plaques in rabbits by suppressing M1 macrophage polarization and promoting M2 polarization through the FOS/MAPK signaling pathway^[6].
临床研究
NCT号适应症或疾病临床期招募状态预计完成时间地点
NCT01764204 - - Completed - -
参考文献

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01764204	-	-	Completed	-	-

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.5749 mL
- 12.8744 mL
- 25.7489 mL
- 5 mM
- 0.5150 mL
- 2.5749 mL
- 5.1498 mL
- 10 mM
- 0.2575 mL
- 1.2874 mL
- 2.5749 mL

技术信息

CAS号

24512-63-8

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C17H24O10

运输

蓝冰

分子量

388.37

别名

栀子苷

溶解度

DMSO	170.0 mg/mL (437.7 mM)
Water	330.0 mg/mL (849.7 mM)

动物实验配方

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